CSF Biobanking Protocol (Cancer with Spread to the Leptomeninges)

Purpose of this Study

We are doing this study to collect cerebrospinal fluid (CSF) samples from people with cancer that has spread to the leptomeninges (the inner membranes that cover the brain and spinal cord). These CSF samples will be used in laboratory research projects to identify substances called biomarkers. Biomarker testing is a way to look for genes, proteins, and other substances (tumor markers) that can provide information about cancer. Information from these CSF samples may help us learn about new methods to treat metastatic disease to the leptomeninges.

Who Can Participate?

Eligibility

Adults ages 18+ who:
  • Have a suspected or confirmed diagnosis of metastatic disease to the leptomeninges
  • Are not participating in another CSF biobanking study at Duke
  • Are not pregnant
For more information about who can join this study, please contact one of the study team members below: Dorothy Sipkins, MD, PhD : dorothy.sipkins@duke.edu or 919-613-5010 Olivia Cupelli: olivia.cupelli@duke.edu or 919-668-1211

Age Range

18-110

Sex/Genders

Male (cisgender)
Female (cisgender)
Non-binary or gender fluid
Transgender male
Transgender female
Looking for Healthy Participants
No

What is Involved?

Description

If you choose to join the study, you will:
  • Have your medical record reviewed
  • Have an extra 5ml (1 teaspoon) of CSF taken at times when you are having a routine lumbar puncture done

Locations

Duke University Hospital

Visit Timing

Weekdays

Compensation

No

Spanish Materials Available

No

Study Details

Full Title

Cerebrospinal Fluid Repository in Adults with Presumed or Diagnosed Metastatic Disease to the Leptomeninges

Principal Investigator

Dorothy
Sipkins

Protocol Number

PRO00113662

Enrollment Status

Open to Enrollment