SiMPLe (Stroke)

Purpose of this Study

We are doing this study to learn more about the connection between the brain and leg muscles in people who have chronic stroke. We want to understand how this connection affects the walking abilities of chronic stroke patients so we can provide better help to stroke patients who need to improve their motor function.

Who Can Participate?

Eligibility

Adults ages 21-85 who:
  • Were diagnosed with their first ever single, unilateral, chronic hemispheric infarction at least 6 months ago
  • Can walk on their own for at least 1 minute
  • Do not have evidence of a brainstem stroke or any other neurologic condition besides stroke
  • Do not have a pacemaker or any intracranial (inside the skull) metallic implants
  • We are also enrolling adults with no history of stroke or any other neurologic condition to participate as a study control group for comparison. For more information, contact the study team at estate.sokhadze@duke.edu.

    Age Range

    21-85

    Sex/Genders

    Male (cisgender)
    Female (cisgender)
    Non-binary or gender fluid
    Transgender male
    Transgender female
    Looking for Healthy Participants
    Yes

    What is Involved?

    Description

    If you choose to join this study, you will visit our clinic 3 times for tests and assessments. These visits will last 2-3 hours and will be done over the course of a week.

    Locations

    Duke University Hospital

    Visit Timing

    Weekdays
    Weekends

    Compensation

    Yes

    Spanish Materials Available

    No

    Study Details

    Full Title

    Neurophysiological quantification of the corticoreticulospinal drive to walking-specific muscles in hemiparetic stroke

    Principal Investigator

    Charalambos
    Charalambous

    Protocol Number

    PRO00115879

    NCT ID

    NA

    Phase

    N/A

    Enrollment Status

    Pending Open to Enrollment