ALADDIN (Aging and Memory Study)

ALADDIN (Aging and Memory Study)

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Purpose of this Study

We are doing this study to help us identify the underlying causes of brain disorders such as delirium and/or dementia.

Who Can Participate?

Eligibility

Adults ages 65+ who:
  • Are scheduled to have surgery in the next few months
  • Are able to speak English
  • Are able to give consent
For more information about the study, please contact the study team at noah.timko@duke.edu.

Age Range

65-110

Sex/Genders

Male (cisgender)
Female (cisgender)
Non-binary or gender fluid
Transgender male
Transgender female
Looking for Healthy Participants
No

What is Involved?

Description

If you choose to join this study, you will:
  • Undergo memory and thinking tests and complete surveys prior to surgery and again 3 months and 1 year after surgery
  • Have a blood draw before surgery and again at 3 months and 1 year after surgery
  • Have a lumbar puncture (spinal tap) and an MRI/fMRI scan before surgery
  • Have your brain activity recorded during surgery through a technique called EEG, which measures brain waves through a thin cap that you wear on your head
To learn more about the study, please watch this video: https://www.youtube.com/watch?v=nLAXWzdeWIk What is it like to undergo a lumbar puncture (spinal tap) with the Duke Anesthesiology study team? Watch these two videos of Dr. Berger discussing the procedure with two past study participants: Video 1: https://www.youtube.com/watch?v=XnMbUKPSDZI Video 2: a href=https://www.youtube.com/watch?v=XtOvEW3WCYM

Locations

Duke University Hospital
Duke Regional Hospital
Duke Raleigh Hospital

Visit Timing

Weekdays
Weekends
Evenings

Compensation

Yes

Spanish Materials Available

No

Study Details

Full Title

Low Neurophysiologic Resistance to Anesthetics as a Marker of Preclinical/Prodromal Alzheimer's Disease and Neurovascular Pathology, Delirium risk and Inattention

Principal Investigator

Michael
Devinney

Protocol Number

PRO00110914

Phase

N/A

Enrollment Status

Open to Enrollment