MRI following Stereotactic Radiosurgery for Brain Metastases

MRI following Stereotactic Radiosurgery for Brain Metastases

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Purpose of this Study

We are doing this study to find out if the study intervention (additional delayed MRI sequences) can tell the difference between radiation damage and tumor recurrence.

Who Can Participate?

Eligibility

Adults ages 18+ who:
  • Have any metastatic solid tumor except small cell lung cancer or myeloma
  • Have at least 1 brain metastasis previously treated with Stereotactic Radiosurgery (SRS) with progression at the treated site(s)
  • Able to have Laser Interstitial Thermal Therapy (LITT)
*If you had whole brain radiotherapy before, that is allowed but not required For more information about who can be in this study, please contact the study team.

Age Range

18-100

Sex/Genders

Male (cisgender)
Female (cisgender)
Non-binary or gender fluid
Transgender male
Transgender female
Looking for Healthy Participants
No

What is Involved?

Description

If you choose to join this study, you will:
  • Have more images taken about 1 hour after your regular MRI
  • Let the study team to collect information from your medical record for 2 years

Locations

Duke University Hospital

Visit Timing

Weekdays

Compensation

No

Spanish Materials Available

No

Study Details

Full Title

Diagnostic Accuracy of Delayed MRI Contrast Enhancement Characteristics and Radiation Necrosis Following Stereotactic Radiosurgery (SRS) for Brain Metastases

Principal Investigator

Scott
Floyd

Protocol Number

PRO00103163

NCT ID

NCT04246879

Phase

Pilot

Enrollment Status

Open to Enrollment
ClinicalTrials.gov