This research study is divided into 3 periods:

• The screening period
• The study drug period
• The follow-up period

If you decide to join this study, you will be enrolled for up to 92 weeks and will visit our clinic 26 times. During the screening period, if this is your last study visit in one of the previous ROCKET studies and your first day on this study, then you will not need to have any of the screening tests and/or procedures completed, unless the study doctor thinks you need to have them done. When you enter the study drug period, you will get a random assignment (like drawing numbers from a hat) to one of three groups:

• You might get a 150mg dose of the study drug; OR
• You might get a 300 mg dose of the study drug; OR
• You might get a placebo (inactive substance with no drug in it)

The study drug/placebo is given as an injection (shot) under the skin about every 4 weeks. The study drug period will last about 72 weeks. While you are in this study, you will have some of the following tests/procedures done:

• Physical exams
• Blood draws
• Skin exams
• EKG

After you stop taking the study drug/placebo, we will schedule you to come in for a follow-up visit about 4 months later.