Purpose of this Study
We are doing this study to find out if an investigational drug called bemcentinib (the study drug) is a safe and effective option when it is combined with the standard therapy for non-small cell lung cancer (1 immunotherapy drug and 2 chemotherapy drugs).
Who Can Participate?
Eligibility
Adults ages 18+ who are diagnosed with advanced non-squamous non-small cell lung cancer.
For more information about who can be in this study, please contact the study team at annmarie.peters@duke.edu.
For more information about who can be in this study, please contact the study team at annmarie.peters@duke.edu.
What is Involved?
If you join this study, you will go through a screening period to make sure you are eligible. During the screening period you will:<ul>
<li>Have blood draws</li>
<li>Have imaging scans (CT and MRI)</li>
<li>Have 2 procedures to check your heart function, an electrocardiogram (ECG) and either an echocardiogram (ECHO) or a multigated acquisition scan (MUGA)</li></ul>
If you are eligible to get the study drug, you will:
<li>Take the study drug by month once per day</li>
<li>Received the standard therapy (1 immunotherapy drug and 2 chemotherapy drugs) every 21 days by injection into a vein (IV)</li></ul>
<li>Have blood draws</li>
<li>Have imaging scans (CT and MRI)</li>
<li>Have 2 procedures to check your heart function, an electrocardiogram (ECG) and either an echocardiogram (ECHO) or a multigated acquisition scan (MUGA)</li></ul>
If you are eligible to get the study drug, you will:
<li>Take the study drug by month once per day</li>
<li>Received the standard therapy (1 immunotherapy drug and 2 chemotherapy drugs) every 21 days by injection into a vein (IV)</li></ul>
Study Details
Full Title
Phase 1b/2a safety and tolerability study of bemcentinib with pembrolizumab/carboplatin/pemetrexed in subjects with untreated advanced or metastatic non-squamous non-small cell lung cancer (NSCLC) without/with a STK11 mutation. (BGBC016 STK11 NSCLC)
Principal Investigator
Laura
Alder
Protocol Number
PRO00112972
NCT ID
NCT05469178
Phase
I/II
Enrollment Status
Open to Enrollment