Clinical Trials Directory

123 clinical trials found.
Cancer Immunotherapy

We are doing this study to find out if an experimental drug called STK-012 (the study drug) is a safe and effective treatment for different types of cancer.

Compensation: No
Oncology
Breast Cancer

We are doing this study to find out if avelumab is a safe and effective option for triple negative metastatic breast cancer when it is combined with different anti-cancer drugs.

Compensation: No
Ages: 18-89
Oncology
Duke University Hospital
Gastrointestinal Cancer

If you choose to join this study, you will:
- Be randomized to Group 1 or Group 2
-- Group 1 will get the study drug (Sulindac)
-- Group 2 will get a placebo (harmless sugar pill)

Both groups will have:
- CT scans (body scan)
- Endoscopy's (a way to look at your digestive tract)
- Collection of cyst fluid from the pancreas

Compensation: No
Ages: 18-85
Oncology
Duke University Hospital, Duke Raleigh Hospital
Gynecologic Cancer

If you choose to join this study, you will:
- Allow us to collect leftover tissue from your surgery, a small blood sample, and urine to use for future research
- Complete study questionnaires
- Agree for us to collect clinical data from your medical record related to your cancer and treatment

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Breast Cancer

If you choose to join this study, you will:
- Be randomized (like the flip of a coin) to screening with Tomosynthesis Mammography (TM) or Digital Mammography (DM)

The frequency and number of screening mammograms will vary with your menopausal status and whether you have breast cancer risk factors.
-- All premenopausal women will have annual screening

-- Postmenopausal women will have screening every 2 years unless they have any specific risk factors

- Have either three-dimensional (3D) Tomosynthesis Mammography or two-dimensional (2D) Digital Mammography

-- Get screened every year for four more years - for a total of five mammograms, or
-- Every other year - for a total of three mammograms

- Be followed for 4.5 to 8 years

Compensation: No
Ages: 40-110
Oncology
Duke University Hospital
Thoracic Cancer

We are doing this study to see how an experimental drug called evolocumab (study drug) works in your body and against your cancer when it is given in combination with approved immunotherapy drugs.

Compensation: No
Ages: 18-100
Oncology
Duke University Hospital, Duke Raleigh Hospital
Brain and Spine Metastasis

We are doing this study to find out if an investigational drug called TYRA-300 (the study drug) is a safe and effective option for patients with locally advanced/metastatic urothelial cancer and other solid tumors.

Compensation: No
Oncology
Primary Brain and Spinal Cord Tumors

We are doing this study to find out the practicality of using a new program called ViSPad on an electronic tablet. We want to know if this program can help reduce anxiety for cancer patients who are having imaging scans done (for example, MRI).

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital